📚 MOTS-c is a 16-amino-acid peptide encoded by mitochondrial DNA, not nuclear DNA like most peptides. Discovered in 2015, it’s part of a rare class of mitochondrial-derived peptides (MDPs) being studied for their ability to regulate metabolism, promote stress resilience, and combat age-related decline.

Unlike other compounds that act downstream in the energy pathway, MOTS-c works upstream, directly influencing cellular energy sensing, fat utilization, and glucose metabolism. This makes it a promising research target for conditions like obesity, insulin resistance, metabolic syndrome, and aging-associated fatigue.

✅ BENEFITS OF MOTS-c

In preclinical studies, MOTS-c has demonstrated:

AMPK activation, mimicking the effects of a calorie deficit.

Improved glucose uptake and insulin sensitivity

Enhanced fat oxidation and mitochondrial biogenesis

Increased endurance and exercise capacity, even in sedentary models

Protection against metabolic stress, oxidative damage, and aging.

It’s especially notable for its potential to reprogram energy metabolism, making it ideal for models involving fat loss and performance enhancement.

⭕️ SIDE-EFFECTS OF MOTS-c

MOTS-c has shown a strong safety profile in animal models. Side effects may include:

Transient fatigue or lethargy, especially at higher doses

Gastrointestinal discomfort

Changes in appetite or blood glucose levels.

There are no reports of hormonal disruption, organ toxicity, or behavioral alterations in short-term studies. However, long-term data remains limited, and all research should be conducted under appropriate laboratory conditions. MOTS-c is not approved for human use.

❓WHO IS IT BEING DEVELOPED FOR?

MOTS-c is being studied in models related to:

Obesity and metabolic syndrome

Insulin resistance and pre-diabetic states

Age-related mitochondrial decline

Performance enhancement without cardiovascular strain

Fatigue and endurance loss due to cellular stress

Its ability to mimic the metabolic effects of exercise and caloric restriction makes it especially appealing for aging research, sedentary models, and enhancement protocols focused on longevity, fat loss, and recovery without overstimulation.

If you are conducting research in those fields, you can get MOTS-c in 10mg vial from our website (sold for research/laboratory use only).